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1T-TaS2 possesses complex electronic phase behaviors in transition-metal di-chalcogenides, undergoing several charge-ordered phases before finally into an insulating state of unknown origin. Here, the authors determine its electronic and structural properties experimentally, revealing its origin.
The direct cleavage of C(CO)−C single bonds is usually restricted to strained ketone substrates or to chelating assistance. Here, the authors show a rhodium(II)-catalyzed three-component reaction of 1,3-diones, diazoesters, and DMF, leading to an unusual formal insertion of O–C(sp3)–C(sp2) into unstrained C(CO)–C bonds.
Xie et al. report a transparent near-infrared light-emitting diode based on semiconducting lead halide perovskite. This technology could enable security and sensing features on space constrained smart-watches, phones, gaming consoles and augmented or virtual reality headsets.
Neurons with grid firing fields are thought to play important roles in spatial cognition. Here, the authors show that in contrast to assumptions underlying current models and analyses, grid fields are modulated by local head direction; this suggests different mechanisms and new roles for grid firing.
Information and communication datacentres require a large amount of energy for their cooling systems, which could be decreased by working at higher temperatures. Here, the authors introduce a silicon-polymer hybrid modulator that maintains high data rates for long periods at high temperatures that could be used under such conditions, to reduce energy consumption.
Intercellular signalling is fundamental for the formation of complex structures from single cells. Here the authors design six orthogonal cell–cell signalling channels for cell consortia communication and bio-computation.
Nematic superconductors, exhibiting rotational-symmetry breaking, can form domains; a counterpart of common magnetic domains. Here, the authors report control of nematic superconductivity and their domains of SrxBi2Se3 by uniaxial deformation, a step toward superconductive domain engineering.
Gallbladder cancer incidence shows characteristic geographic patterns. Here the authors perform a genomic analysis of gallbladder cancers in patients from countries with high incidence (South Korea, India and Chile) and identify ELF3 and other significantly mutated genes not previously associated with gallbladder cancer.
East Antarctic ice shelves typically have cold ice cavities with low basal melt rates. Here the authors direct observational evidence of high basal melt rates beneath Shirase Glacier Tongue in East Antarctica, driven by inflowing warm water guided by a deep continuous trough extending to the continental slope.
Thermal conductivity evidence of a spinon Fermi surface has been rare. Here, the authors report a finite linear increase of thermal conductivity with temperature in Na2BaCo(PO4)2 at ultra-low temperature, suggesting possible gapless quantum spin liquid behavior.
Active colloidal systems can serve as an enabling platform to study complex out-of-equilibrium physical phenomena. Using a magnetic control with a feedback loop, here the authors program the dynamics of active Brownian particles by updating their rotational diffusion coefficient depending on their locations.
In hematopoietic stem cell transplants, T cells mediate graft-versus-leukemia (GVL), but GVL can fail leading to leukemia relapse. Here the authors use a mouse model in which T cells target the minor histocompatibility antigen H60 to show how this can occur, characterize the CD8+ T cell response and demonstrate how anti-CD40 antibody therapy improves GVL.
Phosphatases are key components in cellular signalling networks. Here, the authors present a systematic functional analysis of phosphatases of the fungal pathogen Cryptococcus neoformans, revealing roles in virulence, stress responses, O-mannosylation, retromer function and other processes.
Revealing the spatial distribution of hot carriers in real space is crucial to their efficient utilization. Here, the authors show that in-situ electrochemical tip-enhanced Raman spectroscopy is able to resolve the spatial distribution of reactive hot carriers with a nanometer spatial resolution.
Individuals with PTSD are unable to recollect contextual cues related to the trauma. Here the authors show that this contextual amnesia, associated with the inhibition of hippocampal activity, is causally involved in PTSD-like hypermnesia in mice, and that re-exposure to all trauma-related cues eliminates PTSD-like memory while promoting normal fear memory.
Na+ has been suggested to accumulate in tissues, particularly skin, in a hypertonic manner and to exert local pathogenic effects. Here, we reappraise this phenomenon which is systemic in nature and reflects isotonic changes in the relative extracellular volume in tissues, e.g. subclinical oedema; as such, it occurs in human hypertension and aging.
Direct visualization of moiré superlattices in van der Waals heterostructures is a needed diagnostic tool for the study of periodicity-induced electronic and optical phenomena. Here, the authors demonstrate that the moiré pattern in twisted bilayer graphene can be indirectly imaged by imaging the phonon polariton interference on the top hexagonal boron nitride encapsulation layer.
Light gated reactions are important due to their spatial and temporal control over the chemical processes but long wavelength activation of photocycloaddition reactions are rare. Here the authors introduce a green light induced [2+2] cycloaddition of a halochromic system, which allows for its photo-reactivity to be switched on and off by adjusting the pH of the system.
Here the authors propose an approach to construct metasurfaces, which activate all circularly polarized channels and make full utilization of transmitted energy simultaneously. By introducing chirality-assisted phase all the components in the Jones matrix can be decoupled and independently tuned.
Conventionally, triboelectric nanogenerators are based on static charges fixed on dielectric surfaces. Here, the authors report a new mechanism using shuttling of mirror charge carriers corralled in quasi-symmetrical conduction domains, which boosts performance for blue energy harvesting.
EHBP1 is an adaptor protein that regulates vesicular trafficking and links endosomes to the actin cytoskeleton. Here, authors show that both termini of EHBP1 have membrane targeting potential and that in the absence of its binding partner Rab8, the bMERB and CH domain of EHBP1 form an intramolecular complex which auto-inhibits actin binding.
The diversity of primary sensory neurons and how fate choice is determined is unclear. Here, the authors use single cell RNA sequencing analysis of early murine somatosensory neurons to show that sensory neuron diversity is achieved by a transition through a bi-potential intermediate state.
CdS magic-size clusters have, so far, been prepared only in organic solvents. Here, the authors report an aqueous-phase synthesis for CdS magic-size clusters at room temperature and reveal insights into the formation mechanism, including the key role of primary amines.
Interface chemistry is essential for highly reversible lithium-metal batteries. Here the authors investigate amide-based electrolyte that lead to desirable interface species, resulting in dense Li-metal plating and top-down Li-metal stripping, responsible for the highly reversible cycling.
Blazars show variable non-thermal emission across the electromagnetic spectrum from radio waves to gamma rays. Here, the authors show blazar 3C 279 reveals a characteristic peak-in-peak variability pattern on time scales of minutes if particle acceleration is due to relativistic magnetic reconnection.
Linear mixed models have bias due to the assumed independence between random effects. Here, the authors describe a genome-based restricted maximum likelihood, CORE GREML, which estimates covariance between random effects. Application to UK Biobank data highlights this as an important parameter for multi-omics analyses of phenotypic variance.
Achieving higher efficiencies for thin-film solar cells always requires identification of the limiting factors. Here Krause et al. show that inhomogeneously distributed net doping or lifetime have little impact while recombination at grain boundaries is one of the main loss mechanisms for high performance Cu(In,Ga)Se2 solar cells.
Nearly 17% of all bird species are hosts to obligate brood parasites like the common cuckoo. Antonson et al. show that parasite species hedge their reproductive bets by outsourcing parental care to a greater variety of host species when the rearing environment for their young is more unpredictable.
S. cerevisiae TBP associated factor 14 (Taf14) is a transcriptional regulator that interacts with multiple nuclear complexes. Here, the authors report that the extra-terminal domain of Taf14 (Taf14ET) recognizes a common motif in various transcriptional coactivator proteins and they solve the NMR structure of Taf14ET bound the ET-binding motif of Sth1, the catalytic subunit of the RSC (Remodel the Structure of Chromatin) complex, and furthermore show that Taf14ET undergoes liquid-liquid phase separation, which is enhanced by Taf14 interaction partners.
Living in groups allows animals to decrease defenses, enabling other behaviors, but the mechanisms of safety in numbers are unknown. The authors show that fruit flies regulate freezing behavior as a function of group size and identify motion by others, and neurons that detect it, as key to this process.
Traditional approach to oxidation catalysts relies on metal/oxide supported peripheral interfacial oxygen activity. Here the authors show surface oxygenation of platinum-alloyed multicomponent nanoparticles, and reveals irregular oscillatory kinetics associated with the surface oxygenated sites.
Colossal barocaloric effects with high entropy changes is reported in plastic crystal neopentylglycol, while microscopic mechanism needs to be further explored. Here, the authors show hydrogen bond related reorientational dynamics of neopentylglycol and provide insights in order-disorder transition.
Proteomics is often used to map protein-drug interactions but identifying a drug’s protein targets along with the binding interfaces has not been achieved yet. Here, the authors integrate limited proteolysis and machine learning for the proteome-wide mapping of drug protein targets and binding sites.
The mid-Holocene has seen a number of climate shifts, which have been associated with societal changes. Here, the authors investigate in a centuries long megadrought in Southeast Asia during the mid-Holocene, possibly caused by the end of the Green Sahara period.
Mycobacteria Prim-PolC performs short gap synthesis following removal of lesions during excision repair. Here the authors resolve crystal structures of pre- and post-catalytic Prim-PolC complexes bound to gapped DNA substrates to define its mechanism.
Many psychiatric symptoms are linked to perceptions of danger, particularly when it is uncertain. Here, the authors show that a range of psychiatric symptoms are associated with the way people learn from safe and dangerous outcomes in the context of uncertainty.
It is unclear how biodiversity-ecosystem functioning and species coexistence mechanisms are linked. Here, Godoy and colleagues combine field-parameterised competition models with a BEF experiment to show that mechanisms leading to more stable species coexistence lead to greater productivity, but not necessarily to enhanced functions other than primary production.
Although power laws are observed during nanoindentation and the power-law exponents are estimated to be approximately 1.5-1.6 for face-centered cubic metals, the origin of the exponent remains unclear. In this paper, we show the power-law statistics in pop-in magnitudes and unveil the nature of the exponent.
Biosynthetic gene clusters (BGCs) make small molecules with fitness-enhancing activities that drive BGC evolution. Here, the authors show that synthetic biology can leverage bioactivity to achieve continuous evolution of an antibiotic BGC in the lab and improve antibiotic production in a new host.
Symmetry protected topological states have an impressive robustness to perturbations. Typical examples are topological insulators. Here the authors present a general recipe for constructing crystalline-symmetry protected topological states, valid for both non-interacting and interacting systems.
Electronic implantable devices should be soft and stretchable, such that nerves can adapt mechanically and autonomously. Here, the authors present an adaptive self-healing electronic epineurium which can form compressive stress-free and strain-insensitive electronics-nerve interfaces.
Here, Ejemel et al. report the identification and characterization of a cross-neutralizing human IgA monoclonal antibody, named MAb362, that binds the receptor-binding domain of SARS-CoV-2 Spike, blocking its interaction with the ACE2 host receptor.
A vaccine protecting from SARS-CoV-2 infection is needed. Here the authors generate a replication-incompetent adenovirus based vaccine expressing SARS-CoV-2 spike, show protection from infection in non-human primates, and analyze the immune response after intramuscular and intranasal vaccination.
Modulation of peripheral nervous system signalling has many applications in medicine, neurobiology and machine-man interfaces. Here the authors develop a microscale implantable device for chronic interfacing with a small diameter nerve, and show multi-week in vivo recording and control of activity.
Conventional bioluminescence imaging usually operates in the visible region and its performance is limited by strong tissue absorption and scattering. Here, the authors present bioluminescence probes (BPs) with emission in the second near infrared (NIR-II) region, and show the NIR-II-BPs could sensitively recognize tumor metastasis with a high tumor-to-normal tissue ratio.
Triple negative breast cancer is a deadly form of breast cancer with limited therapeutic options. Here the authors show the efficacy of GLUT1 pharmacological inhibition against a subset of tumors expressing RB1, thereby identifying RB1 protein level as a biomarker of sensitivity to anti-GLUT1 therapy.
Friedreich’s ataxia (FRDA) is an autosomal-recessive disorder. Here the authors describe a DRG organoid from patient derived-neurons and co-culture with muscle cells to mimic the disorder in vitro and demonstrate potential correction of the phenotype by CRISPR based editing.