Article
|
Open Access
Browse Articles
Filters
-
Article Type
-
Year
-
-
Article
| Open AccessRhodium(II)-catalyzed multicomponent assembly of α,α,α-trisubstituted esters via formal insertion of O–C(sp3)–C(sp2) into C–C bonds
The direct cleavage of C(CO)−C single bonds is usually restricted to strained ketone substrates or to chelating assistance. Here, the authors show a rhodium(II)-catalyzed three-component reaction of 1,3-diones, diazoesters, and DMF, leading to an unusual formal insertion of O–C(sp3)–C(sp2) into unstrained C(CO)–C bonds.
- Dan Ba
- , Si Wen
- , Qingyu Tian
- , Yanhui Chen
- , Weiwei Lv
- & Guolin Cheng
-
Article
| Open AccessTransparent near-infrared perovskite light-emitting diodes
Xie et al. report a transparent near-infrared light-emitting diode based on semiconducting lead halide perovskite. This technology could enable security and sensing features on space constrained smart-watches, phones, gaming consoles and augmented or virtual reality headsets.
- Chenchao Xie
- , Xiaofei Zhao
- , Evon Woan Yuann Ong
- & Zhi-Kuang Tan
-
Article
| Open AccessGrid cells are modulated by local head direction
Neurons with grid firing fields are thought to play important roles in spatial cognition. Here, the authors show that in contrast to assumptions underlying current models and analyses, grid fields are modulated by local head direction; this suggests different mechanisms and new roles for grid firing.
- Klara Gerlei
- , Jessica Passlack
- , Ian Hawes
- , Brianna Vandrey
- , Holly Stevens
- , Ioannis Papastathopoulos
- & Matthew F. Nolan
-
Article
| Open AccessHigh-temperature-resistant silicon-polymer hybrid modulator operating at up to 200 Gbit s−1 for energy-efficient datacentres and harsh-environment applications
Information and communication datacentres require a large amount of energy for their cooling systems, which could be decreased by working at higher temperatures. Here, the authors introduce a silicon-polymer hybrid modulator that maintains high data rates for long periods at high temperatures that could be used under such conditions, to reduce energy consumption.
- Guo-Wei Lu
- , Jianxun Hong
- , Feng Qiu
- , Andrew M. Spring
- , Tsubasa Kashino
- , Juro Oshima
- , Masa-aki Ozawa
- , Hideyuki Nawata
- & Shiyoshi Yokoyama
-
Article
| Open AccessDe novo design of an intercellular signaling toolbox for multi-channel cell–cell communication and biological computation
Intercellular signalling is fundamental for the formation of complex structures from single cells. Here the authors design six orthogonal cell–cell signalling channels for cell consortia communication and bio-computation.
- Pei Du
- , Huiwei Zhao
- , Haoqian Zhang
- , Ruisha Wang
- , Jianyi Huang
- , Ye Tian
- , Xudong Luo
- , Xunxun Luo
- , Min Wang
- , Yanhui Xiang
- , Long Qian
- , Yihua Chen
- , Yong Tao
- & Chunbo Lou
-
Article
| Open AccessA discrete serotonergic circuit regulates vulnerability to social stress
Serotonin is important in depression-like behavior. Here the authors show that dorsal raphe neurons that project to the ventral tegmental area are involved in regulating stress responses in mice.
- Wen-Jun Zou
- , Yun-Long Song
- , Min-Yi Wu
- , Xiang-Tian Chen
- , Qiang-Long You
- , Qian Yang
- , Zheng-Yi Luo
- , Lang Huang
- , Yin Kong
- , Jing Feng
- , Dong-Xiang Fang
- , Xiao-Wen Li
- , Jian-Ming Yang
- , Lin Mei
- & Tian-Ming Gao
-
Article
| Open AccessUniaxial-strain control of nematic superconductivity in SrxBi2Se3
Nematic superconductors, exhibiting rotational-symmetry breaking, can form domains; a counterpart of common magnetic domains. Here, the authors report control of nematic superconductivity and their domains of SrxBi2Se3 by uniaxial deformation, a step toward superconductive domain engineering.
- Ivan Kostylev
- , Shingo Yonezawa
- , Zhiwei Wang
- , Yoichi Ando
- & Yoshiteru Maeno
-
Article
| Open AccessIntegrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate
Gallbladder cancer incidence shows characteristic geographic patterns. Here the authors perform a genomic analysis of gallbladder cancers in patients from countries with high incidence (South Korea, India and Chile) and identify ELF3 and other significantly mutated genes not previously associated with gallbladder cancer.
- Akhilesh Pandey
- , Eric W. Stawiski
- , Steffen Durinck
- , Harsha Gowda
- , Leonard D. Goldstein
- , Mustafa A. Barbhuiya
- , Markus S. Schröder
- , Sreelakshmi K. Sreenivasamurthy
- , Sun-Whe Kim
- , Sameer Phalke
- , Kushal Suryamohan
- , Kayla Lee
- , Papia Chakraborty
- , Vasumathi Kode
- , Xiaoshan Shi
- , Aditi Chatterjee
- , Keshava Datta
- , Aafaque A. Khan
- , Tejaswini Subbannayya
- , Jing Wang
- , Subhra Chaudhuri
- , Sanjiv Gupta
- , Braj Raj Shrivastav
- , Bijay S. Jaiswal
- , Satish S. Poojary
- , Shushruta Bhunia
- , Patricia Garcia
- , Carolina Bizama
- , Lorena Rosa
- , Wooil Kwon
- , Hongbeom Kim
- , Youngmin Han
- , Thakur Deen Yadav
- , Vedam L. Ramprasad
- , Amitabha Chaudhuri
- , Zora Modrusan
- , Juan Carlos Roa
- , Pramod Kumar Tiwari
- , Jin-Young Jang
- & Somasekar Seshagiri
-
Article
| Open AccessStrong ice-ocean interaction beneath Shirase Glacier Tongue in East Antarctica
East Antarctic ice shelves typically have cold ice cavities with low basal melt rates. Here the authors direct observational evidence of high basal melt rates beneath Shirase Glacier Tongue in East Antarctica, driven by inflowing warm water guided by a deep continuous trough extending to the continental slope.
- Daisuke Hirano
- , Takeshi Tamura
- , Kazuya Kusahara
- , Kay I. Ohshima
- , Keith W. Nicholls
- , Shuki Ushio
- , Daisuke Simizu
- , Kazuya Ono
- , Masakazu Fujii
- , Yoshifumi Nogi
- & Shigeru Aoki
-
Article
| Open AccessPossible itinerant excitations and quantum spin state transitions in the effective spin-1/2 triangular-lattice antiferromagnet Na2BaCo(PO4)2
Thermal conductivity evidence of a spinon Fermi surface has been rare. Here, the authors report a finite linear increase of thermal conductivity with temperature in Na2BaCo(PO4)2 at ultra-low temperature, suggesting possible gapless quantum spin liquid behavior.
- N. Li
- , Q. Huang
- , X. Y. Yue
- , W. J. Chu
- , Q. Chen
- , E. S. Choi
- , X. Zhao
- , H. D. Zhou
- & X. F. Sun
-
Article
| Open AccessFeedback-controlled active brownian colloids with space-dependent rotational dynamics
Active colloidal systems can serve as an enabling platform to study complex out-of-equilibrium physical phenomena. Using a magnetic control with a feedback loop, here the authors program the dynamics of active Brownian particles by updating their rotational diffusion coefficient depending on their locations.
- Miguel Angel Fernandez-Rodriguez
- , Fabio Grillo
- , Laura Alvarez
- , Marco Rathlef
- , Ivo Buttinoni
- , Giovanni Volpe
- & Lucio Isa
-
Article
| Open AccessT cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect
In hematopoietic stem cell transplants, T cells mediate graft-versus-leukemia (GVL), but GVL can fail leading to leukemia relapse. Here the authors use a mouse model in which T cells target the minor histocompatibility antigen H60 to show how this can occur, characterize the CD8+ T cell response and demonstrate how anti-CD40 antibody therapy improves GVL.
- Meng Zhou
- , Faruk Sacirbegovic
- , Kai Zhao
- , Sarah Rosenberger
- & Warren D. Shlomchik
-
Article
| Open AccessGenome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformans
Phosphatases are key components in cellular signalling networks. Here, the authors present a systematic functional analysis of phosphatases of the fungal pathogen Cryptococcus neoformans, revealing roles in virulence, stress responses, O-mannosylation, retromer function and other processes.
- Jae-Hyung Jin
- , Kyung-Tae Lee
- , Joohyeon Hong
- , Dongpil Lee
- , Eun-Ha Jang
- , Jin-Young Kim
- , Yeonseon Lee
- , Seung-Heon Lee
- , Yee-Seul So
- , Kwang-Woo Jung
- , Dong-Gi Lee
- , Eunji Jeong
- , Minjae Lee
- , Yu-Byeong Jang
- , Yeseul Choi
- , Myung Ha Lee
- , Ji-Seok Kim
- , Seong-Ryong Yu
- , Jin-Tae Choi
- , Jae-Won La
- , Haneul Choi
- , Sun-Woo Kim
- , Kyung Jin Seo
- , Yelin Lee
- , Eun Jung Thak
- , Jaeyoung Choi
- , Anna F. Averette
- , Yong-Hwan Lee
- , Joseph Heitman
- , Hyun Ah Kang
- , Eunji Cheong
- & Yong-Sun Bahn
-
Article
| Open AccessProbing nanoscale spatial distribution of plasmonically excited hot carriers
Revealing the spatial distribution of hot carriers in real space is crucial to their efficient utilization. Here, the authors show that in-situ electrochemical tip-enhanced Raman spectroscopy is able to resolve the spatial distribution of reactive hot carriers with a nanometer spatial resolution.
- Sheng-Chao Huang
- , Xiang Wang
- , Qing-Qing Zhao
- , Jin-Feng Zhu
- , Cha-Wei Li
- , Yu-Han He
- , Shu Hu
- , Matthew M. Sartin
- , Sen Yan
- & Bin Ren
-
Article
| Open AccessPreventing and treating PTSD-like memory by trauma contextualization
Individuals with PTSD are unable to recollect contextual cues related to the trauma. Here the authors show that this contextual amnesia, associated with the inhibition of hippocampal activity, is causally involved in PTSD-like hypermnesia in mice, and that re-exposure to all trauma-related cues eliminates PTSD-like memory while promoting normal fear memory.
- Alice Shaam Al Abed
- , Eva-Gunnel Ducourneau
- , Chloé Bouarab
- , Azza Sellami
- , Aline Marighetto
- & Aline Desmedt
-
Article
| Open AccessTissue sodium excess is not hypertonic and reflects extracellular volume expansion
Na+ has been suggested to accumulate in tissues, particularly skin, in a hypertonic manner and to exert local pathogenic effects. Here, we reappraise this phenomenon which is systemic in nature and reflects isotonic changes in the relative extracellular volume in tissues, e.g. subclinical oedema; as such, it occurs in human hypertension and aging.
- Giacomo Rossitto
- , Sheon Mary
- , Jun Yu Chen
- , Philipp Boder
- , Khai Syuen Chew
- , Karla B. Neves
- , Rheure L. Alves
- , Augusto C. Montezano
- , Paul Welsh
- , Mark C. Petrie
- , Delyth Graham
- , Rhian M. Touyz
- & Christian Delles
-
Author Correction
| Open AccessAuthor Correction: Enhancing droplet deposition through in-situ precipitation
- Maher Damak
- , Md Nasim Hyder
- & Kripa K. Varanasi
-
Article
| Open AccessIn situ nanoscale imaging of moiré superlattices in twisted van der Waals heterostructures
Direct visualization of moiré superlattices in van der Waals heterostructures is a needed diagnostic tool for the study of periodicity-induced electronic and optical phenomena. Here, the authors demonstrate that the moiré pattern in twisted bilayer graphene can be indirectly imaged by imaging the phonon polariton interference on the top hexagonal boron nitride encapsulation layer.
- Yue Luo
- , Rebecca Engelke
- , Marios Mattheakis
- , Michele Tamagnone
- , Stephen Carr
- , Kenji Watanabe
- , Takashi Taniguchi
- , Efthimios Kaxiras
- , Philip Kim
- & William L. Wilson
-
Article
| Open AccessGreen light triggered [2+2] cycloaddition of halochromic styrylquinoxaline—controlling photoreactivity by pH
Light gated reactions are important due to their spatial and temporal control over the chemical processes but long wavelength activation of photocycloaddition reactions are rare. Here the authors introduce a green light induced [2+2] cycloaddition of a halochromic system, which allows for its photo-reactivity to be switched on and off by adjusting the pH of the system.
- Kubra Kalayci
- , Hendrik Frisch
- , Vinh X. Truong
- & Christopher Barner-Kowollik
-
Article
| Open AccessIndependent phase modulation for quadruplex polarization channels enabled by chirality-assisted geometric-phase metasurfaces
Here the authors propose an approach to construct metasurfaces, which activate all circularly polarized channels and make full utilization of transmitted energy simultaneously. By introducing chirality-assisted phase all the components in the Jones matrix can be decoupled and independently tuned.
- Yueyi Yuan
- , Kuang Zhang
- , Badreddine Ratni
- , Qinghua Song
- , Xumin Ding
- , Qun Wu
- , Shah Nawaz Burokur
- & Patrice Genevet
-
Article
| Open AccessPumping up the charge density of a triboelectric nanogenerator by charge-shuttling
Conventionally, triboelectric nanogenerators are based on static charges fixed on dielectric surfaces. Here, the authors report a new mechanism using shuttling of mirror charge carriers corralled in quasi-symmetrical conduction domains, which boosts performance for blue energy harvesting.
- Huamei Wang
- , Liang Xu
- , Yu Bai
- & Zhong Lin Wang
-
Article
| Open AccessThe mechanism of activation of the actin binding protein EHBP1 by Rab8 family members
EHBP1 is an adaptor protein that regulates vesicular trafficking and links endosomes to the actin cytoskeleton. Here, authors show that both termini of EHBP1 have membrane targeting potential and that in the absence of its binding partner Rab8, the bMERB and CH domain of EHBP1 form an intramolecular complex which auto-inhibits actin binding.
- Amrita Rai
- , Nathalie Bleimling
- , Ingrid R. Vetter
- & Roger S. Goody
-
Article
| Open AccessSingle cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates
The diversity of primary sensory neurons and how fate choice is determined is unclear. Here, the authors use single cell RNA sequencing analysis of early murine somatosensory neurons to show that sensory neuron diversity is achieved by a transition through a bi-potential intermediate state.
- Louis Faure
- , Yiqiao Wang
- , Maria Eleni Kastriti
- , Paula Fontanet
- , Kylie K. Y. Cheung
- , Charles Petitpré
- , Haohao Wu
- , Lynn Linyu Sun
- , Karen Runge
- , Laura Croci
- , Mark A. Landy
- , Helen C. Lai
- , Gian Giacomo Consalez
- , Antoine de Chevigny
- , François Lallemend
- , Igor Adameyko
- & Saida Hadjab
-
Article
| Open AccessRoom-temperature formation of CdS magic-size clusters in aqueous solutions assisted by primary amines
CdS magic-size clusters have, so far, been prepared only in organic solvents. Here, the authors report an aqueous-phase synthesis for CdS magic-size clusters at room temperature and reveal insights into the formation mechanism, including the key role of primary amines.
- Wushuang Wan
- , Meng Zhang
- , Min Zhao
- , Nelson Rowell
- , Chunchun Zhang
- , Shanling Wang
- , Theo Kreouzis
- , Hongsong Fan
- , Wen Huang
- & Kui Yu
-
Article
| Open AccessInterface chemistry of an amide electrolyte for highly reversible lithium metal batteries
Interface chemistry is essential for highly reversible lithium-metal batteries. Here the authors investigate amide-based electrolyte that lead to desirable interface species, resulting in dense Li-metal plating and top-down Li-metal stripping, responsible for the highly reversible cycling.
- Qidi Wang
- , Zhenpeng Yao
- , Chenglong Zhao
- , Tomas Verhallen
- , Daniel P. Tabor
- , Ming Liu
- , Frans Ooms
- , Feiyu Kang
- , Alán Aspuru-Guzik
- , Yong-Sheng Hu
- , Marnix Wagemaker
- & Baohua Li
-
Article
| Open AccessGamma-ray flares from relativistic magnetic reconnection in the jet of the quasar 3C 279
Blazars show variable non-thermal emission across the electromagnetic spectrum from radio waves to gamma rays. Here, the authors show blazar 3C 279 reveals a characteristic peak-in-peak variability pattern on time scales of minutes if particle acceleration is due to relativistic magnetic reconnection.
- A. Shukla
- & K. Mannheim
-
Article
| Open AccessCORE GREML for estimating covariance between random effects in linear mixed models for complex trait analyses
Linear mixed models have bias due to the assumed independence between random effects. Here, the authors describe a genome-based restricted maximum likelihood, CORE GREML, which estimates covariance between random effects. Application to UK Biobank data highlights this as an important parameter for multi-omics analyses of phenotypic variance.
- Xuan Zhou
- , Hae Kyung Im
- & S. Hong Lee
-
Article
| Open AccessMicroscopic origins of performance losses in highly efficient Cu(In,Ga)Se2 thin-film solar cells
Achieving higher efficiencies for thin-film solar cells always requires identification of the limiting factors. Here Krause et al. show that inhomogeneously distributed net doping or lifetime have little impact while recombination at grain boundaries is one of the main loss mechanisms for high performance Cu(In,Ga)Se2 solar cells.
- Maximilian Krause
- , Aleksandra Nikolaeva
- , Matthias Maiberg
- , Philip Jackson
- , Dimitrios Hariskos
- , Wolfram Witte
- , José A. Márquez
- , Sergej Levcenko
- , Thomas Unold
- , Roland Scheer
- & Daniel Abou-Ras
-
Article
| Open AccessEcological uncertainty favours the diversification of host use in avian brood parasites
Nearly 17% of all bird species are hosts to obligate brood parasites like the common cuckoo. Antonson et al. show that parasite species hedge their reproductive bets by outsourcing parental care to a greater variety of host species when the rearing environment for their young is more unpredictable.
- Nicholas D. Antonson
- , Dustin R. Rubenstein
- , Mark E. Hauber
- & Carlos A. Botero
-
Article
| Open AccessTaf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation
S. cerevisiae TBP associated factor 14 (Taf14) is a transcriptional regulator that interacts with multiple nuclear complexes. Here, the authors report that the extra-terminal domain of Taf14 (Taf14ET) recognizes a common motif in various transcriptional coactivator proteins and they solve the NMR structure of Taf14ET bound the ET-binding motif of Sth1, the catalytic subunit of the RSC (Remodel the Structure of Chromatin) complex, and furthermore show that Taf14ET undergoes liquid-liquid phase separation, which is enhanced by Taf14 interaction partners.
- Guochao Chen
- , Duo Wang
- , Bin Wu
- , Fuxiang Yan
- , Hongjuan Xue
- , Quanmeng Wang
- , Shu Quan
- & Yong Chen
-
Article
| Open AccessBehavioral and neuronal underpinnings of safety in numbers in fruit flies
Living in groups allows animals to decrease defenses, enabling other behaviors, but the mechanisms of safety in numbers are unknown. The authors show that fruit flies regulate freezing behavior as a function of group size and identify motion by others, and neurons that detect it, as key to this process.
- Clara H. Ferreira
- & Marta A. Moita
-
Article
| Open AccessSurface oxygenation of multicomponent nanoparticles toward active and stable oxidation catalysts
Traditional approach to oxidation catalysts relies on metal/oxide supported peripheral interfacial oxygen activity. Here the authors show surface oxygenation of platinum-alloyed multicomponent nanoparticles, and reveals irregular oscillatory kinetics associated with the surface oxygenated sites.
- Shiyao Shan
- , Jing Li
- , Yazan Maswadeh
- , Casey O’Brien
- , Haval Kareem
- , Dat T. Tran
- , Ivan C. Lee
- , Zhi-Peng Wu
- , Shan Wang
- , Shan Yan
- , Hannah Cronk
- , Derrick Mott
- , Lefu Yang
- , Jin Luo
- , Valeri Petkov
- & Chuan-Jian Zhong
-
Article
| Open AccessUnderstanding colossal barocaloric effects in plastic crystals
Colossal barocaloric effects with high entropy changes is reported in plastic crystal neopentylglycol, while microscopic mechanism needs to be further explored. Here, the authors show hydrogen bond related reorientational dynamics of neopentylglycol and provide insights in order-disorder transition.
- F. B. Li
- , M. Li
- , X. Xu
- , Z. C. Yang
- , H. Xu
- , C. K. Jia
- , K. Li
- , J. He
- , B. Li
- & Hui Wang
-
Article
| Open AccessA machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes
Proteomics is often used to map protein-drug interactions but identifying a drug’s protein targets along with the binding interfaces has not been achieved yet. Here, the authors integrate limited proteolysis and machine learning for the proteome-wide mapping of drug protein targets and binding sites.
- Ilaria Piazza
- , Nigel Beaton
- , Roland Bruderer
- , Thomas Knobloch
- , Crystel Barbisan
- , Lucie Chandat
- , Alexander Sudau
- , Isabella Siepe
- , Oliver Rinner
- , Natalie de Souza
- , Paola Picotti
- & Lukas Reiter
-
Article
| Open AccessEnd of Green Sahara amplified mid- to late Holocene megadroughts in mainland Southeast Asia
The mid-Holocene has seen a number of climate shifts, which have been associated with societal changes. Here, the authors investigate in a centuries long megadrought in Southeast Asia during the mid-Holocene, possibly caused by the end of the Green Sahara period.
- Michael L. Griffiths
- , Kathleen R. Johnson
- , Francesco S. R. Pausata
- , Joyce C. White
- , Gideon M. Henderson
- , Christopher T. Wood
- , Hongying Yang
- , Vasile Ersek
- , Cyler Conrad
- & Natasha Sekhon
-
Article
| Open AccessMolecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C
Mycobacteria Prim-PolC performs short gap synthesis following removal of lesions during excision repair. Here the authors resolve crystal structures of pre- and post-catalytic Prim-PolC complexes bound to gapped DNA substrates to define its mechanism.
- Nigel C. Brissett
- , Katerina Zabrady
- , Przemysław Płociński
- , Julie Bianchi
- , Małgorzata Korycka-Machała
- , Anna Brzostek
- , Jarosław Dziadek
- & Aidan J. Doherty
-
Article
| Open AccessAssociations between aversive learning processes and transdiagnostic psychiatric symptoms in a general population sample
Many psychiatric symptoms are linked to perceptions of danger, particularly when it is uncertain. Here, the authors show that a range of psychiatric symptoms are associated with the way people learn from safe and dangerous outcomes in the context of uncertainty.
- Toby Wise
- & Raymond J. Dolan
-
Article
| Open AccessAn excess of niche differences maximizes ecosystem functioning
It is unclear how biodiversity-ecosystem functioning and species coexistence mechanisms are linked. Here, Godoy and colleagues combine field-parameterised competition models with a BEF experiment to show that mechanisms leading to more stable species coexistence lead to greater productivity, but not necessarily to enhanced functions other than primary production.
- Oscar Godoy
- , Lorena Gómez-Aparicio
- , Luis Matías
- , Ignacio M. Pérez-Ramos
- & Eric Allan
-
Article
| Open AccessUnique universal scaling in nanoindentation pop-ins
Although power laws are observed during nanoindentation and the power-law exponents are estimated to be approximately 1.5-1.6 for face-centered cubic metals, the origin of the exponent remains unclear. In this paper, we show the power-law statistics in pop-in magnitudes and unveil the nature of the exponent.
- Yuji Sato
- , Shuhei Shinzato
- , Takahito Ohmura
- , Takahiro Hatano
- & Shigenobu Ogata
-
Article
| Open AccessA single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders
The substantia nigra is important in neurological disease, particularly movement disorders. Here the authors provide a single cell transcriptomic atlas for the human substantia nigra.
- Devika Agarwal
- , Cynthia Sandor
- , Viola Volpato
- , Tara M. Caffrey
- , Jimena Monzón-Sandoval
- , Rory Bowden
- , Javier Alegre-Abarrategui
- , Richard Wade-Martins
- & Caleb Webber
-
Article
| Open AccessContinuous bioactivity-dependent evolution of an antibiotic biosynthetic pathway
Biosynthetic gene clusters (BGCs) make small molecules with fitness-enhancing activities that drive BGC evolution. Here, the authors show that synthetic biology can leverage bioactivity to achieve continuous evolution of an antibiotic BGC in the lab and improve antibiotic production in a new host.
- Chad W. Johnston
- , Ahmed H. Badran
- & James J. Collins
-
Article
| Open AccessReal-space recipes for general topological crystalline states
Symmetry protected topological states have an impressive robustness to perturbations. Typical examples are topological insulators. Here the authors present a general recipe for constructing crystalline-symmetry protected topological states, valid for both non-interacting and interacting systems.
- Zhida Song
- , Chen Fang
- & Yang Qi
-
Article
| Open AccessAdaptive self-healing electronic epineurium for chronic bidirectional neural interfaces
Electronic implantable devices should be soft and stretchable, such that nerves can adapt mechanically and autonomously. Here, the authors present an adaptive self-healing electronic epineurium which can form compressive stress-free and strain-insensitive electronics-nerve interfaces.
- Kang-Il Song
- , Hyunseon Seo
- , Duhwan Seong
- , Seunghoe Kim
- , Ki Jun Yu
- , Yu-Chan Kim
- , Jinseok Kim
- , Seok Joon Kwon
- , Hyung-Seop Han
- , Inchan Youn
- , Hyojin Lee
- & Donghee Son
-
Article
| Open AccessA cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction
Here, Ejemel et al. report the identification and characterization of a cross-neutralizing human IgA monoclonal antibody, named MAb362, that binds the receptor-binding domain of SARS-CoV-2 Spike, blocking its interaction with the ACE2 host receptor.
- Monir Ejemel
- , Qi Li
- , Shurong Hou
- , Zachary A. Schiller
- , Julia A. Tree
- , Aaron Wallace
- , Alla Amcheslavsky
- , Nese Kurt Yilmaz
- , Karen R. Buttigieg
- , Michael J. Elmore
- , Kerry Godwin
- , Naomi Coombes
- , Jacqueline R. Toomey
- , Ryan Schneider
- , Anudeep S. Ramchetty
- , Brianna J. Close
- , Da-Yuan Chen
- , Hasahn L. Conway
- , Mohsan Saeed
- , Chandrashekar Ganesa
- , Miles W. Carroll
- , Lisa A. Cavacini
- , Mark S. Klempner
- , Celia A. Schiffer
- & Yang Wang
-
Article
| Open AccessAn adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques
A vaccine protecting from SARS-CoV-2 infection is needed. Here the authors generate a replication-incompetent adenovirus based vaccine expressing SARS-CoV-2 spike, show protection from infection in non-human primates, and analyze the immune response after intramuscular and intranasal vaccination.
- Liqiang Feng
- , Qian Wang
- , Chao Shan
- , Chenchen Yang
- , Ying Feng
- , Jia Wu
- , Xiaolin Liu
- , Yiwu Zhou
- , Rendi Jiang
- , Peiyu Hu
- , Xinglong Liu
- , Fan Zhang
- , Pingchao Li
- , Xuefeng Niu
- , Yichu Liu
- , Xuehua Zheng
- , Jia Luo
- , Jing Sun
- , Yingying Gu
- , Bo Liu
- , Yongcun Xu
- , Chufang Li
- , Weiqi Pan
- , Jincun Zhao
- , Changwen Ke
- , Xinwen Chen
- , Tao Xu
- , Nanshan Zhong
- , Suhua Guan
- , Zhiming Yuan
- & Ling Chen
-
Article
| Open AccessPrintable microscale interfaces for long-term peripheral nerve mapping and precision control
Modulation of peripheral nervous system signalling has many applications in medicine, neurobiology and machine-man interfaces. Here the authors develop a microscale implantable device for chronic interfacing with a small diameter nerve, and show multi-week in vivo recording and control of activity.
- Timothy M. Otchy
- , Christos Michas
- , Blaire Lee
- , Krithi Gopalan
- , Vidisha Nerurkar
- , Jeremy Gleick
- , Dawit Semu
- , Louis Darkwa
- , Bradley J. Holinski
- , Daniel J. Chew
- , Alice E. White
- & Timothy J. Gardner
-
Article
| Open AccessNIR-II bioluminescence for in vivo high contrast imaging and in situ ATP-mediated metastases tracing
Conventional bioluminescence imaging usually operates in the visible region and its performance is limited by strong tissue absorption and scattering. Here, the authors present bioluminescence probes (BPs) with emission in the second near infrared (NIR-II) region, and show the NIR-II-BPs could sensitively recognize tumor metastasis with a high tumor-to-normal tissue ratio.
- Lingfei Lu
- , Benhao Li
- , Suwan Ding
- , Yong Fan
- , Shangfeng Wang
- , Caixia Sun
- , Mengyao Zhao
- , Chun-Xia Zhao
- & Fan Zhang
-
Article
| Open AccessGLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer
Triple negative breast cancer is a deadly form of breast cancer with limited therapeutic options. Here the authors show the efficacy of GLUT1 pharmacological inhibition against a subset of tumors expressing RB1, thereby identifying RB1 protein level as a biomarker of sensitivity to anti-GLUT1 therapy.
- Qin Wu
- , Wail ba-alawi
- , Genevieve Deblois
- , Jennifer Cruickshank
- , Shili Duan
- , Evelyne Lima-Fernandes
- , Jillian Haight
- , Seyed Ali Madani Tonekaboni
- , Anne-Marie Fortier
- , Hellen Kuasne
- , Trevor D. McKee
- , Hassan Mahmoud
- , Michelle Kushida
- , Sarina Cameron
- , Nergiz Dogan-Artun
- , WenJun Chen
- , Yan Nie
- , Lan Xin Zhang
- , Ravi N. Vellanki
- , Stanley Zhou
- , Panagiotis Prinos
- , Bradly G. Wouters
- , Peter B. Dirks
- , Susan J. Done
- , Morag Park
- , David W. Cescon
- , Benjamin Haibe-Kains
- , Mathieu Lupien
- & Cheryl H. Arrowsmith
-
Article
| Open AccessFrataxin gene editing rescues Friedreich’s ataxia pathology in dorsal root ganglia organoid-derived sensory neurons
Friedreich’s ataxia (FRDA) is an autosomal-recessive disorder. Here the authors describe a DRG organoid from patient derived-neurons and co-culture with muscle cells to mimic the disorder in vitro and demonstrate potential correction of the phenotype by CRISPR based editing.
- Pietro Giuseppe Mazzara
- , Sharon Muggeo
- , Mirko Luoni
- , Luca Massimino
- , Mattia Zaghi
- , Parisa Tajalli-Tehrani Valverde
- , Simone Brusco
- , Matteo Jacopo Marzi
- , Cecilia Palma
- , Gaia Colasante
- , Angelo Iannielli
- , Marianna Paulis
- , Chiara Cordiglieri
- , Serena Gea Giannelli
- , Paola Podini
- , Cinzia Gellera
- , Franco Taroni
- , Francesco Nicassio
- , Marco Rasponi
- & Vania Broccoli