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. 2020 May;17(5):259-260.
doi: 10.1038/s41569-020-0360-5.

COVID-19 and the cardiovascular system

Ying-Ying Zheng  1   2 , Yi-Tong Ma  3 , Jin-Ying Zhang  4   5 , Xiang Xie  6
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Free PMC article

COVID-19 and the cardiovascular system

Ying-Ying Zheng et al. Nat Rev Cardiol. .
Free PMC article
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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells through ACE2 receptors, leading to coronavirus disease (COVID-19)-related pneumonia, while also causing acute myocardial injury and chronic damage to the cardiovascular system. Therefore, particular attention should be given to cardiovascular protection during treatment for COVID-19.

Conflict of interest statement

The authors declare no competing interests.

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References

    1. Wang D, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020 doi: 10.1001/jama.2020.1585. - DOI - PubMed
    1. Zhou P, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020 doi: 10.1038/s41586-020-2012-7. - DOI
    1. Huang C, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506. doi: 10.1016/S0140-6736(20)30183-5. - DOI - PMC - PubMed
    1. Turner AJ, Hiscox JA, Hooper NM. ACE2: from vasopeptidase to SARS virus receptor. Trends Pharmacol. Sci. 2004;25:291–294. doi: 10.1016/j.tips.2004.04.001. - DOI - PMC - PubMed
    1. Alhogbani T. Acute myocarditis associated with novel Middle East respiratory syndrome coronavirus. Ann. Saudi Med. 2016;36:78–80. doi: 10.5144/0256-4947.2016.78. - DOI - PMC - PubMed

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