Liver injury during highly pathogenic human coronavirus infections

doi:10.1111/liv.14435

Review

. 2020 May;40(5):998-1004.

doi: 10.1111/liv.14435. Epub 2020 Mar 30.

Liver injury during highly pathogenic human coronavirus infections

Ling Xu^{1

2}, Jia Liu^{1

2}, Mengji Lu^{2

3}, Dongliang Yang^{1

2}, Xin Zheng^{1

2}

Affiliations

¹ Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, China.
³ Institute for Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.

PMID: 32170806
PMCID: PMC7228361
DOI: 10.1111/liv.14435

Free PMC article

Review

Liver injury during highly pathogenic human coronavirus infections

Ling Xu et al. Liver Int. 2020 May.

Free PMC article

. 2020 May;40(5):998-1004.

doi: 10.1111/liv.14435. Epub 2020 Mar 30.

Authors

Ling Xu^{1

2}, Jia Liu^{1

2}, Mengji Lu^{2

3}, Dongliang Yang^{1

2}, Xin Zheng^{1

2}

Affiliations

¹ Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, China.
³ Institute for Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.

PMID: 32170806
PMCID: PMC7228361
DOI: 10.1111/liv.14435

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Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), the pathogen of 2019 novel coronavirus disease (COVID-19), has posed a serious threat to global public health. The WHO has declared the outbreak of SARS-CoV-2 infection an international public health emergency. Lung lesions have been considered as the major damage caused by SARS-CoV-2 infection. However, liver injury has also been reported to occur during the course of the disease in severe cases. Similarly, previous studies have shown that liver damage was common in the patients infected by the other two highly pathogenic coronavirus - severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV), and associated with the severity of diseases. In this review, the characteristics and mechanism of liver injury caused by SARS-CoV, MERS-CoV as well as SARS-CoV-2 infection were summarized, which may provide help for further studies on the liver injury of COVID-19.

Keywords: COVID-19; MERS; SARS; SARS-CoV-2; liver injury.

Conflict of interest statement

The authors disclose no conflicts of interest.

Comment in

Let's not forget our COVID-19-free cirrhotic patients!
Viganò M, Carbone M. Viganò M, et al. Liver Int. 2020 Jun;40(6):1508-1509. doi: 10.1111/liv.14460. Epub 2020 Apr 24. Liver Int. 2020. PMID: 32329551 No abstract available.

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References

1. Su S, Wong G, Shi W, et al. Epidemiology, genetic recombination, and pathogenesis of coronaviruses. Trends Microbiol. 2016;24(6):490‐502. - PMC - PubMed
1. Peiris J, Lai ST, Poon L, et al. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003;361(9366):1319‐1325. - PMC - PubMed
1. Kupferschmidt K. Researchers scramble to understand camel connection to MERS. Science. 2013;341(6147):702. - PubMed
1. Zhu NA, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727‐733. - PMC - PubMed
1. Drosten C, Günther S, Preiser W, et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med. 2003;348(20):1967‐1976. - PubMed

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[1] Su S, Wong G, Shi W, et al. Epidemiology, genetic recombination, and pathogenesis of coronaviruses. Trends Microbiol. 2016;24(6):490‐502. - PMC - PubMed

[2] Su S, Wong G, Shi W, et al. Epidemiology, genetic recombination, and pathogenesis of coronaviruses. Trends Microbiol. 2016;24(6):490‐502. - PMC - PubMed

[3] Peiris J, Lai ST, Poon L, et al. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003;361(9366):1319‐1325. - PMC - PubMed

[4] Peiris J, Lai ST, Poon L, et al. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003;361(9366):1319‐1325. - PMC - PubMed

[5] Kupferschmidt K. Researchers scramble to understand camel connection to MERS. Science. 2013;341(6147):702. - PubMed

[6] Kupferschmidt K. Researchers scramble to understand camel connection to MERS. Science. 2013;341(6147):702. - PubMed

[7] Zhu NA, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727‐733. - PMC - PubMed

[8] Zhu NA, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727‐733. - PMC - PubMed

[9] Drosten C, Günther S, Preiser W, et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med. 2003;348(20):1967‐1976. - PubMed

[10] Drosten C, Günther S, Preiser W, et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med. 2003;348(20):1967‐1976. - PubMed

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Liver injury during highly pathogenic human coronavirus infections

Affiliations

Liver injury during highly pathogenic human coronavirus infections

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Cited by 72 articles

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Abstract

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Cited by 72 articles

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