Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings
- PMID: 32205284
- PMCID: PMC7270493
- DOI: 10.1016/j.ijid.2020.03.040
Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings
Abstract
Purpose: To investigate the epidemiological and clinical characteristics of COVID-19 patients with abnormal imaging findings.
Methods: Patients confirmed with SARS-CoV-2 infection in Zhejiang province from January 17 to February 8 who had undergone CT or X-ray were enrolled. Epidemiological and clinical data were analyzed among those with abnormal or normal imaging findings.
Results: Excluding 72 patients with normal images, 230 of 573 patients showed abnormalities affecting more than two lung lobes. The median radiographic score was 2.0, and there was a negative correlation between that score and the oxygenation index (ρ = -0.657, P < 0.001). Patients with abnormal images were older (46.65 ± 13.82), with a higher rate of coexisting condition (28.8%), a lower rate of exposure history, and longer time between onset and confirmation (5 days) than non-pneumonia patients (all P < 0.05). A higher rate of fever, cough, expectoration and headache, a lower level of lymphocytes, albumin, and serum sodium levels and a higher total bilirubin, creatine kinase, lactate dehydrogenase, and C-reactive protein levels and a lower oxygenation index were observed in pneumonia patients (all P < 0.05). Muscle ache, shortness of breath, nausea and vomiting, lower lymphocytes levels, and higher serum creatinine and radiographic score at admission were predictive factors for the severe/critical subtype.
Conclusion: Patients with abnormal images have more obvious clinical manifestations and laboratory changes. Combing clinical features and radiographic scores can effectively predict severe/critical types.
Keywords: Clinical; Epidemiological; Imaging findings; Predictive factors; SRAS-CoV-2.
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.
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