Cardiovascular complications in COVID-19

doi:10.1016/j.ajem.2020.04.048

Review

. 2020 Jul;38(7):1504-1507.

doi: 10.1016/j.ajem.2020.04.048. Epub 2020 Apr 18.

Cardiovascular complications in COVID-19

Brit Long¹, William J Brady², Alex Koyfman³, Michael Gottlieb⁴

Affiliations

¹ Brooke Army Medical Center, Department of Emergency Medicine, 3841 Roger Brooke Dr, Fort Sam Houston, TX 78234, United States. Electronic address: brit.long@yahoo.com.
² Department of Emergency Medicine, University of Virginia School of Medicine, Charlottesville, VA 22903, United States. Electronic address: WB4Z@hscmail.mcc.virginia.edu.
³ The University of Texas Southwestern Medical Center, Department of Emergency Medicine, 5323 Harry Hines Boulevard, Dallas, TX 75390, United States.
⁴ Department of Emergency Medicine, Rush University Medical Center, Chicago, IL 60612, United States.

PMID: 32317203
PMCID: PMC7165109
DOI: 10.1016/j.ajem.2020.04.048

Free PMC article

Review

Cardiovascular complications in COVID-19

Brit Long et al. Am J Emerg Med. 2020 Jul.

Free PMC article

. 2020 Jul;38(7):1504-1507.

doi: 10.1016/j.ajem.2020.04.048. Epub 2020 Apr 18.

Authors

Brit Long¹, William J Brady², Alex Koyfman³, Michael Gottlieb⁴

Affiliations

¹ Brooke Army Medical Center, Department of Emergency Medicine, 3841 Roger Brooke Dr, Fort Sam Houston, TX 78234, United States. Electronic address: brit.long@yahoo.com.
² Department of Emergency Medicine, University of Virginia School of Medicine, Charlottesville, VA 22903, United States. Electronic address: WB4Z@hscmail.mcc.virginia.edu.
³ The University of Texas Southwestern Medical Center, Department of Emergency Medicine, 5323 Harry Hines Boulevard, Dallas, TX 75390, United States.
⁴ Department of Emergency Medicine, Rush University Medical Center, Chicago, IL 60612, United States.

PMID: 32317203
PMCID: PMC7165109
DOI: 10.1016/j.ajem.2020.04.048

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Abstract

Background: The coronavirus disease of 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While systemic inflammation and pulmonary complications can result in significant morbidity and mortality, cardiovascular complications may also occur.

Objective: This brief report evaluates cardiovascular complications in the setting of COVID-19 infection.

Discussion: The current COVID-19 pandemic has resulted in over one million infected worldwide and thousands of death. The virus binds and enters through angiotensin-converting enzyme 2 (ACE2). COVID-19 can result in systemic inflammation, multiorgan dysfunction, and critical illness. The cardiovascular system is also affected, with complications including myocardial injury, myocarditis, acute myocardial infarction, heart failure, dysrhythmias, and venous thromboembolic events. Current therapies for COVID-19 may interact with cardiovascular medications.

Conclusions: Emergency clinicians should be aware of these cardiovascular complications when evaluating and managing the patient with COVID-19.

Keywords: Acute myocardial infarction; COVID-19; Cardiovascular; Dysrhythmia; Heart failure; Infectious disease; Myocarditis; Troponin.

Published by Elsevier Inc.

Conflict of interest statement

Declaration of competing interest None.

Figures

Fig. 1

COVID-19 and the cardiovascular system.

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References

1. World Health Organization WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020. https://www.who.int/dg/speeches/detail/whodirector-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020 Available online at.
1. Coronavirus Disease 2019 (COVID-19) Centers for Disease Control and Prevention. https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/cases-in-us.html
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1. Driggin E., Madhavan M.V., Bikdeli B. Cardiovascular considerations for patients, health care workers, and health systems during the coronavirus disease 2019 (COVID-19) pandemic. J Am Coll Cardiol. Mar 18 2020 [pii: S0735-1097(20)34637-4, in press] - PMC - PubMed
1. Wu Z., McGoogan J.M. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention. JAMA. Feb 24 2020 doi: 10.1001/jama.2020.2648. [Epub ahead of print] - DOI - PubMed

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[1] World Health Organization WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020. https://www.who.int/dg/speeches/detail/whodirector-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020 Available online at.

[2] World Health Organization WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020. https://www.who.int/dg/speeches/detail/whodirector-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020 Available online at.

[3] Coronavirus Disease 2019 (COVID-19) Centers for Disease Control and Prevention. https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/cases-in-us.html

[4] Coronavirus Disease 2019 (COVID-19) Centers for Disease Control and Prevention. https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/cases-in-us.html

[5] World Health Organization Situation report. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200403-sitrep-74-covid-19-mp.pdf?sfvrsn=4e043d03_4

[6] World Health Organization Situation report. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200403-sitrep-74-covid-19-mp.pdf?sfvrsn=4e043d03_4

[7] Driggin E., Madhavan M.V., Bikdeli B. Cardiovascular considerations for patients, health care workers, and health systems during the coronavirus disease 2019 (COVID-19) pandemic. J Am Coll Cardiol. Mar 18 2020 [pii: S0735-1097(20)34637-4, in press] - PMC - PubMed

[8] Driggin E., Madhavan M.V., Bikdeli B. Cardiovascular considerations for patients, health care workers, and health systems during the coronavirus disease 2019 (COVID-19) pandemic. J Am Coll Cardiol. Mar 18 2020 [pii: S0735-1097(20)34637-4, in press] - PMC - PubMed

[9] Wu Z., McGoogan J.M. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention. JAMA. Feb 24 2020 doi: 10.1001/jama.2020.2648. [Epub ahead of print] - DOI - PubMed

[10] Wu Z., McGoogan J.M. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention. JAMA. Feb 24 2020 doi: 10.1001/jama.2020.2648. [Epub ahead of print] - DOI - PubMed

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Cardiovascular complications in COVID-19

Affiliations

Cardiovascular complications in COVID-19

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Conflict of interest statement

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Cited by 18 articles

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Cited by 18 articles

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