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Research Article
Daisy-chain gene drives for the alteration of local populations
Charleston Noble, John Min, Jason Olejarz, Joanna Buchthal, Alejandro Chavez, Andrea L. Smidler, Erika A. DeBenedictis, View ORCID ProfileGeorge M. Church, View ORCID ProfileMartin A. Nowak, and View ORCID ProfileKevin M. Esvelt
PNAS April 23, 2019 116 (17) 8275-8282; first published April 2, 2019 https://doi.org/10.1073/pnas.1716358116
Charleston Noble
aProgram for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138;
bDepartment of Genetics, Harvard Medical School, Boston, MA 02115;
John Min
bDepartment of Genetics, Harvard Medical School, Boston, MA 02115;
cMedia Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139;
dWyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138;
Jason Olejarz
aProgram for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138;
Joanna Buchthal
cMedia Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139;
dWyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138;
Alejandro Chavez
bDepartment of Genetics, Harvard Medical School, Boston, MA 02115;
dWyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138;
eDepartment of Pathology, Massachusetts General Hospital, Boston, MA 02114;
Andrea L. Smidler
fDepartment of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115;
Erika A. DeBenedictis
cMedia Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139;
George M. Church
bDepartment of Genetics, Harvard Medical School, Boston, MA 02115;
dWyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138;
Martin A. Nowak
aProgram for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138;
gDepartment of Mathematics, Harvard University, Cambridge, MA 02138;
hDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138
Kevin M. Esvelt
cMedia Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139;
Contributed by George M. Church, July 15, 2018 (sent for review September 22, 2017; reviewed by Chase Beisel and John M. Marshall)
Daisy-chain gene drives for the alteration of local populations
Charleston Noble, John Min, Jason Olejarz, Joanna Buchthal, Alejandro Chavez, Andrea L. Smidler, Erika A. DeBenedictis, George M. Church, Martin A. Nowak, Kevin M. Esvelt
Proceedings of the National Academy of Sciences Apr 2019, 116 (17) 8275-8282; DOI: 10.1073/pnas.1716358116
Citation Manager Formats
Daisy-chain gene drives for the alteration of local populations
Charleston Noble, John Min, Jason Olejarz, Joanna Buchthal, Alejandro Chavez, Andrea L. Smidler, Erika A. DeBenedictis, George M. Church, Martin A. Nowak, Kevin M. Esvelt
Proceedings of the National Academy of Sciences Apr 2019, 116 (17) 8275-8282; DOI: 10.1073/pnas.1716358116
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- Applied Biological Sciences
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