Production of hornless dairy cattle from genome-edited cell lines

Nature Biotechnology volume 34, pages479–481(2016)Cite this article

Subjects

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

Rent or Buy

All prices are NET prices.

Figure 1: Phenotypic and genotypic confirmation of POLLED introgression in Spotigy and Buri.

References

  1. 1

    Bouie, F. A. The dehorning debate. Farm Animal Welfare News 2 (2002).

  2. 2

    Spurlock, D.M., Stock, M.L. & Coetzee, J.F. J. Dairy Sci. 97, 5265–5274 (2014).

    CAS  Article  Google Scholar 

  3. 3

    Stafford, K.J. & Mellor, D.J. Vet. J. 169, 337–349 (2005).

    CAS  Article  Google Scholar 

  4. 4

    Wilcox, C.S., Schutz, M.M., Rostagno, M.R., Lay, D.C. Jr. & Eicher, S.D. J. Dairy Sci. 96, 7223–7233 (2013).

    CAS  Article  Google Scholar 

  5. 5

    Swanson, A.F. Wanted: more bulls with no horns. NPR The Salt http://www.npr.org/sections/thesalt/2015/08/03/429024245/wanted-more-bulls-with-no-horns (3 August, 2015).

    Google Scholar 

  6. 6

    Dorshorst, B. Half of Holstein heifer calves could be polled by 2034. Progressive Dairyman (17 January, 2014). http://www.progressivedairy.com/topics/a-i-breeding/half-of-holstein-heifer-calves-could-be-polled-by-2034.

    Google Scholar 

  7. 7

    Tan, W.S., Carlson, D.F., Walton, M.W., Fahrenkrug, S.C. & Hackett, P.B. Adv. Genet. 80, 37–97 (2012).

    CAS  Article  Google Scholar 

  8. 8

    Medugorac, I. et al. PLoS One 7, e39477 (2012).

    CAS  Article  Google Scholar 

  9. 9

    Rothammer, S. et al. Genetics Selection Evolution 46, 1–5 (2014).

    Article  Google Scholar 

  10. 10

    Tan, W. et al. Proc. Natl. Acad. Sci. USA 110, 16526–16531 (2013).

    CAS  Article  Google Scholar 

  11. 11

    Ross, P.J. & Cibelli, J.B. Methods Mol. Biol. 636, 155–177 (2010).

    Article  Google Scholar 

Download references

Author information

Affiliations

  1. Recombinetics, St. Paul, Minnesota, USA

    Daniel F Carlson, Cheryl A Lancto, Eui-Soo Kim, Mark Walton, Tad S Sonstegard & Scott C Fahrenkrug

  2. Program in Scientific Computation, University of Minnesota, Minneapolis, Minnesota, USA

    Bin Zang

  3. Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas, USA

    David Oldeschulte & Christopher Seabury

Authors
  1. Daniel F Carlson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Cheryl A Lancto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bin Zang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Eui-Soo Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mark Walton
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. David Oldeschulte
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Christopher Seabury
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Tad S Sonstegard
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Scott C Fahrenkrug
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Scott C Fahrenkrug.

Ethics declarations

Competing interests

D.F.C., C.A.L., E.S.K., T.S.S. and S.C.F. are employees of Recombinetics; D.F.C., C.A.L., E.S.K., M.W., T.S.S. and S.C.F. are shareholders in Recombinetics.

Additional information

Editor's note: This article has been peer-reviewed.

Supplementary information

Supplementary Table and Text

Supplementary Table 1 and Supplementary Methods (PDF 167 kb)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Carlson, D., Lancto, C., Zang, B. et al. Production of hornless dairy cattle from genome-edited cell lines. Nat Biotechnol 34, 479–481 (2016). https://doi.org/10.1038/nbt.3560

Download citation

Further reading